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As the name suggests, this is a form of cell death caused by copper, in which copper ions directly bind to protein lipoylation components in the tricarboxylic acid circulation pathway, causing abnormal aggregation of lipoylated proteins and loss of iron-sulfur cluster protein, resulting in protein toxic stress responses and cell death (172)

Current recommendations suggest that cystatin C measurement be used in combination with creatinine testing to confirm kidney disease diagnosis in patients with reduced GFR (4559 mL/min) but no other signs of kidney damage (Shlipak, Mattes 2013)

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This is a class effect of GLP-1 receptor agonists

- No usar en pacientes con inestabilidad hemodinmica