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Mechanism 1: RF triggers fibroblast collagen synthesis RF works by passing controlled electromagnetic energy through the skin, generating thermal energy at depths of 1 to 4mm that brings dermal temperature to roughly 40 to 45C

Cell migration and ECM

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The first is that the exact formulation is not published, so if something goes wrong your clinician cannot tell a hospital precisely what was injected

In general, the proinflammatory M1 phenotype manifests in glucose uptake and glycolysis, 150 while the anti-inflammatory M2 phenotype manifest in OXPHOS and the TCA cycle activity

Assumptions and Limitations 3