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Light microscopy images showed a concentration-dependent reduction in cell density following HC treatment in A375 and SK-MEL-28 cells, but not in HDFs (Supplementary Figure S1)

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The authors framed the study around the hypothesis that simultaneous activation of GIP, GLP-1, and GCG receptors could produce different neurobiological effects compared with previously studied single- or dual-receptor agonists

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Known elements in insulin signaling pathways were probed to understand how cotadutide modulated specific insulin-stimulated phosphopeptides at the molecular level