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Genetic variation also plays a role in how efficiently your GLP-1 system functions

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113 In a physiological context, the vast majority of cellular ROS is produced in mitochondria using NADH as electron donor

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In the trials of these drug classes, tirzepatide (the SURMOUNT program) produced average weight loss roughly in the 15% to 21% range across doses at about 72 weeks, while semaglutide (the STEP program) produced around 15% at about 68 weeks