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Researchers at the University of Oxford found that beta-arrestin mediated desensitization in pancreatic beta cells recovered within six hours of agonist removal

This suggests an inhibitory GABAergic signal from the GIPR agonists dampens GLP-1R-mediated aversive, avoidant, or emetic signals, which may be accomplished by unique projections of GIPR neurons to GLP-1R + neurons in the AP ( Figure 4 )

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