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Pre-specified covariates included mean pre-treatment HbA 1c , mean HbA 1c after treatment initiation, largest recorded drop in HbA 1c post treatment initiation, diabetes duration, mean arterial pressure (MAP), pre-existing retinal status, pre-existing microalbuminuria or albuminuria, LDL-cholesterol and prior use of oral hypoglycaemic agents (OHAs), GLP-1RAs or insulin