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Some of the most common side effects from clinical trials include: Headache (2538%) Nausea (2158%) Trouble sleeping (1524%) Weakness (1620%) Dizziness (1124%) Ejaculation disorder (219%) Sleepiness or drowsiness (1226%) Dry mouth (1222%) Sweating (719%) Loss of appetite (1517%) Nervousness (1726%) Constipation (915%) Delayed, infrequent or absent orgasms (513%) Other less serious side effects of venlafaxine that have been reported include: Weight loss (16%) Vision changes such as blurred vision (46%) Hypertension (high blood pressure) (25%) Impotence (46%) Tingling or numbness (23%) Tremor (110%) Vomiting (38%) Weight gain (2%) Gas (34%) Itching (1%) Yawning (38%) Indigestion (57%) Twitching (13%) Dilated pupils (2%) Most of these side effects will resolve on their own