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Like other GLP-1 class drugs, retatrutide is expected to be used as ongoing chronic treatment rather than a fixed-length course

As a result of this rapid degradation, only about 10-15% of released GLP-1 reaches the pancreas intact

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The dual glucose-dependent insulinotropic peptide and glucagon-like peptide-1 receptor agonist, tirzepatide, improves lipoprotein biomarkers associated with insulin resistance and cardiovascular risk in patients with type 2 diabetes

Through these interactions, GLP-1 and GLP-1RAs influence appetite and food intake but also reward mechanisms, which may be very important for the clinical effects of the agonists

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