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Menopause 31(5):p 363-371, May 2024

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The first direct empirical evidence for this principle emerged nearly three centuries later from the work of German pharmacologist Hugo Schulz

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PYC activates Nrf2-dependent transcription, increasing antioxidant defenses such as GSH and SOD, and suppresses ROS-sensitive NF-B signaling, thereby reducing oxidative stress and associated pro-inflammatory responses (Grimm et al., 2004

As a master antioxidant, GSH directly scavenges reactive oxygen species and serves as a co-substrate for glutathione peroxidase (GPx), underpinning critical processes including detoxification, DNA synthesis, and immune regulation