2) GLP-1RAPDB2022GLP-1RA60.52018-2022CAGR70.5%(~16%)(~55%) GLP-1RA GLP-1RA202251%15%;202274.4(31%)GLP-1R/GIPR20225FDA2022/2023Q14.8/5.72030GLP-1RA2350-400GLP-18GLP-1RA2%2NDA7III9II(2023.3) FDA6(Saxenda)201412GLP-1RA;Ozempic(2017,)Rybelsus(2019,)Wegovy(2021);Tirzepatide(Mounjaro)GIPR/GLP-1R20225IIGLP-1(2023.7) GLP-1(2023.7)1(2023.7)(2023.7)GLP-1R/GIPRGLP-1R/GCGRGLP-1R/GIPRGLP-1R/GCGRGLP-1R/GCGRIBI362IIIGLP-1R/GIPR/GCGRRetatrutideIIIGLP-1R/AMYRCagriSemaIII2)GLP-1RAOrforglipronDanuglipronLotiglipronOrforglipron(II)III3)GLP-1RAFcPEG/GLP-1efpeglenatideIII4)GLP-12 GLP-1 FDAGLP-1RACDMO 1 GLP-1RA 1.1 GLP-1RA 1.1.1 GLP-1 (GLP-1)L1964 60-70% T2DM 20% GLP-1()GLP-1GLP-1 1.1.2 GLP-1 GLP-1()()50mg/dLGLP-1T2DM(ISR) GLP-1 2 1.1.3 GLP-1 GLP-1 GLP-1 934021.8mg13%22% 232972(MACE) 1.1.4 GLP-1 RA GLP-1 GLP-13 (DPP-4)(DPP-4)1-2minGLP-1DPP-4GLP-1 RAGLP-1RA23N()DPP-4GLP-1()Fc()PEG()PLGA() 1.2 GLP-1RA200 1.2.1 GLP-1RA 2005GLP-1RA GLP-1Exendin-4GLP-153%2009GLP-1GLP-197%GLP-1RAGLP-1RAGLP-1RA 1)GLP-1RA 2)GLP-1RA 3)GLP-1RA GLP-1RAExendin-4(GLP-1)GLP-1GLP-1RA 1.2.2 GLP-1RA GLP-1RA 2018-2022SGLT-2iGLP-1RA33%29%CAGRDPP-4i20235GLP-15.5%(5%0.5%)39%(36%3%) GLP-1RA20020311500 2023Q13940(591)GLP-11570(235.5)39.8%2031GLP-116501000 1.2.3 GLP-1RA GLP-1 GLP-1RAPDB2018GLP-1RA6.8202260.52018-2022CAGR70.5%Frost & Sullivan2030GLP-1RA515 GLP-1(~16%)(~55%) 1)GLP-1GLP-12)GLP-13)GLP-1RA(ASCVD)GLP-1RA 2 GLP-1RA 2.1 2.1.1 (IDF)20215.3720457.841.4112.8 Frost & Sullivan2020697202590020301100202039%GLP-1(18.8%)DPP-4(17.4%)SGLT-2(10.8%)GLP-1 2.1.2 20211.4120451.752022IO(International Operations)19%(23%)(40-50%) -Frost & Sullivan202063245.1%202511612020-202512.9% 2.2 GLP-1ADAGLP-1 2(T2DM)GLP-1ASCVDCKD 202142(2020)GLP-1T2DMGLP-1RA3(+/) T2DMASCVDGLP-1RAICKDSGLT2iGLP-1RA 2023ADAGLP-1RA 202212ADA2023T2DMT2DMT2DMASCVD/HF/CKDGLP-1RAs()(GIP)/GLP-1RA(tirzepatide)GLP-1RA 2.3 GLP-1(GLP-1 RA)-(SU(TZDs)-4(DPP-4i)--2(SGLT-2i)GLP-1 RA GLP-1 1)GLP-12)GLP-1,3)4)GLP-1RA2(T2DM) 2.4 GLP-1RA (1)-GLP-1RA GLP-1GLP-153%GLP-1RA2005GLP-1RA2-4h2 HbA1c 0.5%~1.0% 1030HbA1c7%40%0.9% 30 (10 )+22.6kg (TZD) 40%-50%Excendin-438%( 85% GLP-1RANAFLD/NASHIII F2-3NASHIII202112007251)NASH(72)2)NASH(72)3)(0-240)2029 GCGRGIPRFGF21R 20236(EASL)GLP-1GCGRefinopegdutide(MK-6024)NAFLD)IIaefinopegdutideGLP-1145efinopegdutide(10mg)(1mg)24efinopegdutide72.7%(95% CI66.878.7)42.3%(95% CI36.548.1)24efinopegdutide8.5%7.1%(p=0.085)IIb2025.12.5 4.5.2 (AD): III (AD) ADAD()AD(MCI)ADAD-(A)(NFTs) GLP-1RA TauGLP-1RA1)GLP-1ADAD2)GLP-1GLP-1RAT2DM15%19%GLP-13)GLP-1 GLP-1RAAD ADGLP-1RAAb/Tau III104CDR-SB2025 5 5.1 GLP-1 5.1.1 (1982)leuprolidegoserelin(19851989)20902000-20101990-20102 5.1.2 2-99() FDA Frost & Sullivan202062820259602019-20258.8%CDMO2020202025442019-202517.7% 5.1.3 FDA6% 1940FDA6%83%11%FDA 2023H1Top108 5.1.4 1) 2) 5.1.4 BocFmoc 1)DICDCCEDCHClHOBtHOAt2)TBTUHBTUHATUPyBOP 5.1.4 + 1000kgMounjaroAPI 42.5mg/0.5mL5mg/0.5mL415mg(Mounjaro2.5mg7.5mg10mg12.5mg15mg)5mg/0.5mLDrugs.com(5mg/)~1087 1000kg5000543.5 IIISURPASS-3521000kg400 5.1.5 GLP1-RA GLP-1RACDMO 2021API20194Polypeptide2020API1865%35%GLP-1RAGMPCDMO 5.2 5.2.1 GLP-1 2023H14650%GLP-18 1)HDM1002(GLP-1R) 20235IND20236/IND20239 2)HDM1005(GLP-1R/GIPR) 2024IND 3)DR10624 (GLP-1R/GCGR/FGF21R) 20237I(MAD)IND20237IND20236IND20238 4) 20233NMPA20236NMPA 5) IIII 6) IIII 5.2.2 843000202382BCMA CAR-TPCSK910 PCSK9202383IBI362(GLP-1R/GCGR/2)IBI128(XOI)IBI311(IGF-1R)4III IBI112(IL-23p19)IBI302(VEGF/C)2023H124.6(+20.4%)23Q235%(PD-1) 5.2.3 31 2023H149.62153(PD-L1)(DPP-42) 6 SHR-1314(IL-17A)SHR0302(JAK1)SHR8058(NOV03)SHR8028(A)SHR-1209(PCSK9)HRX0701(DPP-4/2)80270GLP-1 5.2.4 5185%202230%2022115%500020222023-2025361190% (Sandoz)BLA 201812SandozSandoz23002023FDABLAGlobalNewswire2021550 GZR18(GLP-1)GZR4()GZR101() 5.2.5 20225202214.9%100% 2011GLP-1RA20226URAT1 2022III202212GLP-1RA17 5.2.6 ()CDMO 2018CDMO/CMO2022CDMO 2023Wuxi TIDES2022Wuxi TIDES20.82023H113.370%2023H1TIDES207(+46%)121(+25%)2023H132(+68%)TIDESAPICMCTIDES30%TIDESCMC CRDMO 2023H1Wuxi TIDES4(37)6(14)1(6)11GLP-1Wuxi TIDESCRDMO2022Wuxi TIDES6000L20232wL20243.2wL20224.3522023162024312023 5.2.7 5kg20221.9(+126.3%)GLP-1RA1SPN00920227GLP-1/GIPSPN0072022920002023522cGMP1.021 (Cipla)(Cadila)Orbicular(Teva)(Dr.Reddy202111FDA(Active)202312CDE 1060.20.1520210002 5.2.8 2022CDMO1.1(+10.3%)1.4(+55.2%)1.4(-42.2%) 5.2.9 CDMO CDMO CDMO(mAb)(ADC)RNA (mRNA)CDMOCROCDMOCDMO 202210(+150.5%)3.34(+113.2%)CDMO(33.4%-5.9pp)3.7(+138.7%)20224068Phase II25-CDMO-- 20224035 5.2.10 20232692415105 202216DMF5DMF5CEP14DMF20220.9(+59.4%)112% 5.2.11 CDMO CDMO/IIIIII2023H11NDA29 III66III839NDA 202342023H12023H2 5.2.12 7-ACA20223.2(+58%) 2022seplife2-CTCsieberGLP-1sieber 5.2.13 CDMO CDMO CDMOcGMP5002012GLP-1/ cGMP 16cGMP1000L5000L300kg 5 GLP-1RA 2023919 ( SACS1250520030002 2022 /CAR-TNASHPD-1BTKCLDN18.2GLP-1HIVG-CSFADCESMOASCOCSCOEGFR CGM | | | | | | | | CXOCDMO CXO | CXO 2023H12023H1 mRNAHPVDelta | A |||| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | || | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | -B| | | | | | | | | | | | | | | | | (NVO) | (MSD) | (JNJ) | (ABBV) | (AMGN) | (SNY) | (AZN) | (PFE)
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Normalmente, se necesitan varias sesiones, entre cinco y diez, para obtener unos resultados ptimos
Skin over the age of 40, however, typically has reduced structural support and slower collagen renewal, which means laxity, hollowness and sagging tend to appear sooner and more noticeably
Do not inject semaglutide from a vial with a compromised seal
The inter-crural space beneath the columella is separated by tenotomy scissors ( Fig
