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Subcutaneous injection adverse events in published peptide research are predominantly mild and local: injection site erythema (redness) occurs in approximately 515% of subjects, pruritus (itching) in 310%, and subcutaneous nodule formation in less than 2%

When lactate concentration in the TME exceeds 20 mM, it may induce NK cell apoptosis

Adults should not exceed 4,000 mg per day

The full therapeutic dose may not be reached until 16 to 20 weeks after initiation, which delays maximal efficacy but improves tolerability and treatment adherence

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Employers face the tough decision of either spending millions or increasing premiums, in the event that they want to add GLP-1 coverage to their prescription drug benefits program