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37 Thus, we may here hypothesise that at least in mice, the predominant impact of cagrilintide through AMY 1 R contributed to the observed reduction in fat mass in WT mice compared to the KO mice

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At the epigenetic level, decreasing NAD + /NADH ratio with age inhibits SIRT1/3 activity and impairs PGC-1-mediated mitochondrial biosynthesis and antioxidant gene expression [292, 293]

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