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Overall, neonatal pain management and sedation encounter gaps in evidence and practice, emphasizing the need for standardization, improved personalized approaches based on pharmacokinetic and pharmacodynamic maturation, multimodal strategies to minimize opioid and benzodiazepine exposure, and rigorous studies of new therapies to ensure safe, effective, and equitable care for newborns

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However, the effectiveness of these proteins largely depends on their structural integrity, which is often altered during processing (Nunes & Tavares, 2019)

Initially developed for type 2 diabetes, these therapies are now being explored for obesity, cardiovascular disease, and neurological conditions