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The Real Problem Is Not Stopping

Endocrinology 144 , 52425248 (2003)

Receptor Downregulation Findings and Study Design Implications A well-documented finding in the research literature is that continuous IGF-1 receptor activation leads to receptor downregulation after approximately four to six weeks, reducing cellular responsiveness to further stimulation

If constipation persists beyond 3 weeks despite multiple interventions, consult your prescribing provider

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SURMOUNT-1 was published in 2022, and the trial included 2539 nondiabetic adults who were either obese or overweight with at least one weight-related complication