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Has the ability to effect key hormone without containing the hormones it self

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Inhibition of IKK and TBK1 improves glucose control in a subset of patients with type 2 diabetes

Oxyntomodulin is a biased agonist relative to GLP-1 4 , and forms distinct and more dynamic interactions with the GLP-1R, particularly with residues at the base of the peptide binding cavity that is located above the conserved central polar network that is important for receptor activation