tirzepatide and not losing weight Why Am I on Tirzepatide? 💊 Heard conflicting things about

This process applies to compounded semaglutide, compounded tirzepatide, and any GLP-1 medication supplied in a multi-dose vial

Dried lipid pellets were dissolved in 200 L of cholesterol assay buffer

25 mg/day oral Tirzepatide 15 mg/week Retatrutide 12 mg/week Liraglutide 3.0 mg/day Factor Peak trial weight loss Semaglutide -14.9% at 68 wks (STEP 1) Tirzepatide -22.5% at 72 wks (SURMOUNT-1) Retatrutide -28.7% at 68 wks (TRIUMPH-4) Liraglutide -8% at 56 wks (SCALE) Factor FDA status (June 2026) Semaglutide Approved (T2D, obesity, CVD, MASH, CKD, oral) Tirzepatide Approved (T2D, obesity) Retatrutide Investigational - Phase 3 Liraglutide Approved (Saxenda obesity, Victoza T2D) Factor CV outcomes data Semaglutide Yes - SELECT (20% MACE drop) Tirzepatide SURPASS-CVOT ongoing Retatrutide TRIUMPH-3 ongoing Liraglutide Yes - LEADER (13% MACE drop) These compounds are not interchangeable

Liu Z et al

This shows that L-carnitine acts as a "transporter" in fat metabolism

But GLP-1 skin depletion also involves real losses in collagen and structural support that require a longer-term approach