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When compared to BBR alone single dose (50 mg/kg) oral pharmacokinetic studies in rats revealed a significant improvement in the variance of mean residence time peak plasma concentration and area under the curve of BBR-SLNs indicating improved bioavailability

Subjects included in the population pharmacokinetic analysis were randomized to a maintenance dose of either 0.5 mg or 1.0 mg semaglutide once weekly

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