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These preclinical models may not fully replicate the complexity and heterogeneity of human tumors

Montalban-Bravo G, Kanagal-Shamanna R, Benton, Class C, Chien K, Sasaki K, Naqvi K, Alvarado Y, Kadia T, Ravandi F, Cortes J, Daver N, Takahashi K, DiNardo C, Jabbour E, Borthakur G, Pemmaraju N, Konopleva M, Pierce S, Bueso-Ramos C, Andreeff M , Patel K, Kantarjian H, and Garcia-Manero G

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They also reduce appetite and delay gastric emptying, or slow the rate at which food leaves the stomach

Downregulation of PD-L1 expression by melatonin, which suppresses HCC cells proliferation and migration through regulation of HIF-1 and MAPK/JNK-p38 signaling, are also believed to be receptor-independent