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447 Furthermore, astrocytic atrophy and reduced presence of astrocytes around synapses affects synaptic maintenance, glutamate homoeostasis, and K + buffering thus affecting neuronal excitability and limiting synaptic plasticity

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In the HARMONY-2 (efficacy and safety of once-weekly GLP-1 receptor agonist albiglutide) clinical study, patients were randomized to receive either once-weekly albiglutide (30 mg, titrated up to 50 mg if required for glycemic control) or 10 units of insulin glargine once daily

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