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The specific preparation route I is shown as follows: wherein, the substituent R in the compound 1, the compound 2 and the compound 4 is alkyl such as alkane, alkene, alkyne or aromatic hydrocarbon

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Therefore, these results revealed that the Caspase 3-mediated apoptosis was inhibited by ebselen and was aggravated by the lack of GPX1 in SGNs after peroxynitrite injury