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7 Synaptic dysfunction, neurotransmitter imbalance and neuroinflammation are closely related to the progression of AD

Various drugs, often used off-label, aim to lower ICP, but some of them negatively affect cognitive abilities

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Preclinical studies demonstrate that DSIP can alter pain threshold responses, with observed effects that are not reversed by opioid receptor antagonists such as naloxone, suggesting involvement of non-opioid or indirect neuromodulatory pathways [7]

Furthermore we approached both the Netherlands Pharmacovigilance Centre Lareb on January 17 th 2023 and the Teratology Information Service (TIS) of Switzerland on February 6 th 2023