On the other hand, the experiment was conducted in accordance with the ARRIVE (Animal Research: Reporting of in Vivo Experiments) guidelines [63] for the care and use of research animals Consent for publication NA Competing interests The authors declare that they have no conflict of interest
[1] [3] Physical and chemical properties [edit] Lipoic acid contains two sulfur atoms connected by a disulfide bond in the 1,2-dithiolane ring
Sulfur index analysis (sulfur metabolomics) Sulfur index analysis was carried out using S -bimanyl derivatives through LC MS/MS (Shimadzu Nexera UHPLC system with on-line LCMS 8040, Kyoto, Japan), as previously described 59,60,61,62
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In general, ROS signaling in eryptosis is less diverse compared to nucleated cells, since in erythrocytes, ROS mainly mediate PS externalization by modulating Ca 2+ influx, while in nucleated cells, there are multiple signaling pathways downstream of ROS involved in the execution of apoptosis