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The official prescribing information does mention depression under the Postmarketing Experience listing

Combats weight loss fatigue Supports workout performance Maintains mental clarity Reduces afternoon crashes Appetite Regulation Inositol helps regulate insulin sensitivity and may reduce cravings for sugary and high-carb foods, making it easier to stick to your nutrition plan

Individuals with Vitamin B12 Deficiency: Through blood testing, we can confirm a B12 deficiency and provide immediate treatment with injections if necessary

Is this harmful, and what could be causing it

It can include extreme tiredness or exhaustion that prevents you from doing activities of normal life

The human bodys daily requirement of B12 is considered to be between 1.5 2 g, although the intake itself must be slightly higher, as not all B12 can be absorbed from food sources or supplements