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AMY1R and AMY3R are the predominant subtypes expressed in the area postrema and hypothalamic nuclei relevant to energy balance regulation (Hay et al., British Journal of Pharmacology, 2015)

The same study demonstrated that loss of either HMGCR or FDPS leads to upregulation of arachidonic acid metabolism, which promotes ferroptosis, and our transcriptomic analysis replicated this finding in YR1.7 and MC38 [60]