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This is a distinct yet similar immunologic phenomenon as immune reconstitution inflammatory syndrome (IRIS) in patients with HIV, which occurs following antiretroviral therapy initiation (29)

Carretero Gmez J, Ena J, Segu Ripoll JM et al (2020) Early biomarkers of diabetic kidney disease

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In most animals, the reproductive system ages at the same rate as other tissues in the body, and does not enter a phase of senescence where function shuts down well before everything else

10.1371/journal.pone.0108157 21 ChenT.ZhangX.ZhuG.LiuH.ChenJ.WangY.et al (2020)