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Pregnancy, breastfeeding, and acute pancreatitis are absolute contraindications

Morello et al., 2018)

[1] [2] According to NICE guideline NG28 (Type 2 diabetes in adults: management), GLP-1 receptor agonists may be considered when metformin is contraindicated or not tolerated, or when other treatments have not achieved adequate glycaemic control, particularly in patients with a BMI 35 kg/m (or lower in certain ethnic groups) or when weight loss would provide additional clinical benefit

Why it matters for weight loss: You can mobilize all the fat you want, but if it can't get into your mitochondria to be burned, it just gets re-deposited elsewhere

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Vitamin B12 is a water-soluble vitamin essential for red blood cell formation, nerve function, and DNA synthesis