In addition to its effects on insulin, GIP plays a crucial role in fat accumulation by promoting the activity of adipocyte-expressed lipoprotein lipase and promoting bone formation by preventing osteoclast apoptosis, as evidenced by the thinner bone trabeculae seen in mice lacking GIP receptors [20,21,22]
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This large-scale retrospective cohort study drew on electronic health record data for 60,860 adults aged 40 years or older with both type 2 diabetes and obesity enrolled in the TriNetX US network between December 2017 and June 2024
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