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If you are taking antidepressants, benzodiazepines, sleep medications, pain medications, or blood pressure drugs, the alcohol interaction picture becomes considerably more complex

Liu BH, Zhou L, Tan KTH, Siu X-Y, Guan

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But they often lead to muscle loss and may trigger metabolic adaptations that slow your progress over time or make it difficult to sustain your weight loss

Nearly half of participants lost more than 30% of their body weight, with some severe obesity patients exceeding 30% weight loss after two years of continuous treatment