5-Amino-1MQ (5-amino-1-methylquinolinium) is the most studied inhibitor of nicotinamide N-methyltransferase (NNMT) an enzyme that acts as a metabolic brake in fat cells by depleting both SAM (S-adenosylmethionine) and NAD+ precursors
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Archier E, Devaux S, Castela E, Gallini A, Aubin F, Le Maitre M,
[DOI] [PMC free article] [PubMed] [Google Scholar] 113.Spannuth W.A., Nick A.M., Jennings N.B., Armaiz-Pena G.N., Magala L.S., Danes C.G., Ling Y.G., Merritt W.M., Thaker P.H., Kamat A.A., et al
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In our DR model, Epitalon treatment prevented HG-induced hypomethylation in ARPE-19 cells, as assessed by global 5 mC levels (Supplementary Fig