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Astrocytes contribute to the stability of the neuronal microenvironment [41] and react to tissue injury by increasing the expression of GFAP, an intermediate filament protein expressed by astrocytes [42, 43]

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Glutathione reductase (GR) reduces glutathione disulfide (GSSG) and drives the GSH-dependent systems [7,8], whereas Trx reductases (TrxR) are pivotal in the Trx-dependent system (Figure 1) [9]

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