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PPIs, antibiotics, anticonvulsants, hormone replacement therapy, hormonal birth control, metformin, and GLP-1s (indirectly) can deplete B12

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A potentially serious adverse effect of GLP-1 receptor agonists

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16 weeks (2 daily + 1 weekly) 176 syringes 160 daily + 16 weekly

The duration problem might be mitigated via coadministration with a PDE5 inhibitor, which yielded good results in a small 2005 study.8 Yet research on this approach remains limited