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Notably, MET formation may also be induced by hormonal changes as demonstrated in a study of monocytes purified from peripheral blood of non-pregnant women during the menstrual cycle which showed that (a) more METs are produced during the luteal phase compared to the follicular phase and (b) revealed a positive correlation between the number of METs and serum levels of progesterone [55] (Fig

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Consequently , researchers use these models to study how localized blood-flow regulation responds to tissue stress or controlled experimental injury