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Exclusion criteria included any pharmacological treatment of the gastrointestinal tract, systemic antibiotics within the last 3 months, probiotics or low-FODMAP-diet within the last 3 weeks, vegan or vegetarian diet, regular use of analgesics, pregnancy, prior gastrointestinal surgery apart from appendectomy (16)

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Hypothesized Synergy Combined relevance of Tesamorelin and Mod GRF may generate a prolonged baseline of GHRH receptor stimulation, while Ipamorelin may suppress somatostatin's inhibitory tone and directly stimulate GH release via GHSR