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It is considered safe to use during pregnancy or breastfeeding and should not have any negative effects

The absence of liver toxicity with orforglipron, despite its primary route of elimination through hepatic CYP3A-mediated metabolism, suggests that the hepatotoxicity observed with danuglipron and lotiglipron was related to the specific chemical structures of those molecules rather than to the class of small-molecule GLP-1 agonists as a whole

If you experience severe, persistent abdominal pain while taking a GLP-1 receptor agonist, seek urgent medical attention

doi:10 } : CS1 maint: DOI inactive as of July 2025 (link) "Hepatitis C virus entry: molecular mechanisms and targets for antiviral therapy"

444,445 Its low cost and limited adverse reactions make it a commonly used drug for the treatment of UC