This has potential implications for the use of PSA for prostate cancer detection in obese men
I couldnt find a specific reason for it being denied by Health Canada but I suspect it is due to Phentermines history with Fen-Phen
Clinical data and real-world use show that most weight loss happens over several months, not the first few weeks
They may suggest adjusting the dose, slowing the titration schedule, or prescribing anti-nausea medication to help you stay on track with treatment
Consumers comparing GLP-1 options often weigh: FDA-approved medications like injectable Wegovy and Zepbound, and now oral Wegovy, offer the most extensive clinical trial data, full FDA regulatory oversight, and established safety profiles
Briefly, at typical physiological GSH concentrations and pH, the reaction between ONOO - and GSH will predominantly be a two electron oxidation process leading to GSSG formation (Quijano et al., 1997)