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A proteolytic enzyme, dipeptidyl peptidase-4 (DPP-4), binds to and destroys GLP-1 molecules in the blood in minutes

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However, several melanocytomas arise de novo (without a pre-exsisting common nevus): for example, cases of pure (non-combined) PEM are also genetically peculiar because often they harbor kinase (most commonly PRKA , but also NTRK1 and NTRK3 ) (38) fusions as the initiating event