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How that IGF-1 signal balances against the appetite and energy-expenditure arms is exactly the kind of question human trials exist to answer, and the reported "without muscle loss" result is a conference readout, not a peer-reviewed journal analysis

doi: 10.1111/ene.13439 3 AbeysingheADeshapriyaRUdawatteC

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Lyon: IARC (2018)

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*Compounded formulations of GLP-1s are not reviewed by the FDA for safety, efficacy, or quality