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Thats why its important not to exceed the C rating recommended by the manufacturer

The decision

When those products are unavailable, too costly, or clinically suboptimal (for example, a patient needing a concentration not commercially available), compounded testosterone from a 503B facility is a reasonable clinical choice

2.1.1 Monoamine transporter disruption and neurotransmitter release METH disrupts the reuptake and enhances the release of dopamine, serotonin, and norepinephrine, significantly increasing their extracellular concentrations

10.1016/j.toxlet.2016.10.006 87

The risk of GERD-related complications was greater (RR, 1.55