203 Therefore, reviews or intervention strategies discussing SIRT1 in MASLD must avoid the oversimplified assumption that SIRT1 activation is always beneficial and instead adopt a refined, stage- and cell-specific framework
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Baseline assessment must include psychiatric stability (patient should be on a stable sertraline dose for at least 4 weeks), fasting glucose or HbA1c, renal function, and history of gastrointestinal disorders
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