Additionally, studies should consider taking a 3-day food record before GLP-1RA begins, during treatment, and follow-up to better determine the changes of nutrient intake
PS, performance status
Very few investigational medicines have indications for all the clinical manifestations of PCOS, although melatonin combined with other therapeutics or supplementation (metformin, magnesium) has shown some benefits across the whole spectrum of symptoms
With the lower cost of the drug, that number is likely to increase
With time, the risk of endometrial cancer increases drastically, which is a reason tamoxifen is typically recommended for 5 years
Evidence from pre-clinical studies showed that castration notably inhibits protein levels of PGC-1 and TFAM, and reduces mitochondrial biogenesis in the skeletal muscle of rats, mice, and pigs (82, 83)