GLP-1 therapy is ideal for adults with a BMI of 30 or greater, or a BMI of 27 or greater with at least one weight-related health condition, who have struggled with other weight loss methods
We knew from previous research that being overweight and having excess body fat is a recognized risk factor for insulin resistance and type 2 diabetes, which complicate cancer therapy, says Thomas George, MD, a professor of medicine and interim director of the University of Florida Health Cancer Institute in Gainesville and one of the study authors
In the December 2025 TRIUMPH-4 Phase 3 topline report, adults with obesity and knee osteoarthritis lost an average of 28.7% of body weight at 68 weeks in the highest studied arm
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These studies highlight the broad effect of GLP-1-based therapies and its potential application value
There are a number of healthy eating patterns that can serve as the foundation for dietary advice (e.g., Mediterranean, DASH [Dietary Approaches to Stop Hypertension], and plant-based diets)
