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To enable clinical application, further high-quality preclinical studies and well-designed clinical trials are necessary to validate its efficacy and clarify the underlying mechanisms of action

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Lappas M, Permezel M, Rice GE: N-Acetyl-cysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-kappaB deoxyribonucleic acid-binding activity in human fetal membranes in vitro