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Although a prior cohort study did not show a statistically significant reduction in major cardiovascular events among patients with no previous history of cardiovascular disease [148], a meta-analysis of eight clinical trials evaluating the effect of GLP-1R agonists on cardiovascular outcomes reported a 14% reduction in major adverse cardiovascular events, with no significant heterogeneity across GLP-1R agonists or subgroups, including patients with or without previous cardiovascular disease [149]

A further step toward understanding synaptic plasticity in inhibitory neurons would require knowledge of forms and mechanisms of plasticity that can be induced by natural patterns of activity, typical for each specific type of inhibitory neurons

There have been no reports of successful reversal of this operation

Figure 1 depicts the possible modulatory effects of plant secondary metabolites on the cell signaling pathways