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Thus, a British study showed that patients already with liver failure who then received the N-acetyl cysteine were more likely to survive than patients who did not receive the antidote

Stupnisek et al., 2015)

They rarely describe failure states: persistent cloudiness from aggregated peptide, gel-like consistency from incomplete dissolution of a large pellet, or a precipitate forming hours after initial clarity due to slow aggregation

Specifically in regard to nausea, it tended to be most pronounced in the first 4 weeks of therapy in all phase III LEAD trials, with symptoms generally dissipating over the remainder of the study period

Ethics statement The trial was conducted in accordance with the Declaration of Helsinki (1996 revision) and under the principals of good clinical practice, as laid out in the International Conference on Harmonization document Good Clinical Practice Consolidated Guideline