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Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status, and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmia)

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Ipamorelin and Hexarelin instead act on the ghrelin receptor (GHS-R1a) in the pituitary and hypothalamus, triggering GH release through a separate pathway