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When you engage in physical activity, your body burns calories for energy

These mice exhibited a 24% reduction in the size of cortical bone and shortened femur length compared with controls, whereas trabecular bone density and connectivity were increased

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Patients who tolerate dose increases well and progress to the 14 mg maintenance dose typically achieve greater glycemic improvements than those who remain at 7 mg

These alterations enhance albumin binding, slow elimination, and extend circulation time, resulting in prolonged therapeutic activity and sustained receptor engagement

This triangulation between biopsy, NITs, and systemic cardiometabolic measures helps validate the biological plausibility of the treatment effect and supports the use of NITs in future biopsy-sparing strategies