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The mechanism involves deactivating the tyrosinase enzyme responsible for skin pigmentation

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Systemic toxicity is extremely low (Pickart et al., BioMed Res Int 2012)

In particular, they found that incubation of erythrocytes with CD4 + T lymphocytes, inhibited T cell proliferation and the expression of IL-2 and cytokines specific of Th1, Th2 and Th17 cells, without promoting differentiation towards T regulatory cells