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Both glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) have individually been shown to reduce cardiovascular and kidney outcomes in patients with T2DM, with a low hypoglycemia risk [3, 4]

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Joint Pain: Paradoxically, users may experience joint pain, counteracting any performance benefits

Slow dosing and supportive nutrition strategies can make symptoms more manageable, allowing patients to stay on therapy and benefit from its weight-loss and metabolic effects

Available at: New England Journal of Medicine+1 Ladenheim EE