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Using heteronuclear nuclear Overhauser effect (hetNOE) experiments, we determined the essential regions of the p53 TAD for binding to the FOXO4 forkhead domain (FHD)

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Different analyzers used in high resolution MS, including time of flight (TOF), and Orbitrap enable the determination of the elemental composition (assignment of the most probable sum formula) of a compound by measuring the exact mass and comparing the isotopic profile of the obtained spectrum with the theoretical profile

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