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In bovine mammary-gland research, DES stimulated local cell proliferation at doses 10-fold lower than native IGF-1, demonstrating potency that is site-specific rather than systemic [11]

Under normal physiological conditions, this pathway is well regulated, but its dysregulation is common to numerous types of cancer, in which it drives uncontrolled cell division, cell survival and metastasis [116, 117]

10.1038/s41598-022-25269-0 35 HouX.PovinecP

This amount allows researchers to maintain consistent daily dosing while monitoring effects throughout the active period

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